Research progress on dexmedetomidine for the prevention of delirium in intensive care unit

VernacularTitle:右美托咪定防治重症加强治疗病房谵妄的研究进展
Author: Xueyan ZHANG ; Xiaochen SUN ; Zhifeng LI ; Feng JIN ; Jianguo LI
Publication Type:Journal Article
Keywords: Delirium; Dexmedetomidine; Intensive care unit
From: Chinese Critical Care Medicine 2016;28(4):381-384
CountryChina
Language:Chinese
Abstract: In the clinical practice,critically ill patients are in great risk of delirium because of the impact of psychological,surroundings,illness,and medications,with the incidence rate as high as 45％-87％.Delirium could result in bad prognosis and clinical consequences of cognitive function in late stage.Dexmedetomidine (DEX) is a novel and highly selective 2-adrenoceptor agonist.It offers beneficial pharmacological properties and has been widely used in intensive care unit (ICU).In order to provide scientific and effective references for clinical practice,this paper reviewed the development of DEX intervention for the prevention of delirium in ICU both in China and abroad refereed to the pharmacological characteristics and the efficiency in clinic and the influence factors ofthe efficiency;and also discussed the possible mechanisms,such as modulating the neurotransmitters,and attenuating stress response and inflammation.