Advances in metabolic response to stress during critical illness
10.3760/cma.j.issn.2095-4352.2016.04.020
- VernacularTitle:危重病应激性代谢反应的研究进展
- Author:
Qingrong ZHANG
;
Lulong BO
;
Xiaoming DENG
- Publication Type:Journal Article
- Keywords:
Critical illness;
Metabolic response;
Stress
- From:
Chinese Critical Care Medicine
2016;28(4):377-380
- CountryChina
- Language:Chinese
-
Abstract:
The metabolic response to stress plays a key role in the adaptive response during critical illness.Multiple mechanisms including the stimulation of the sympathetic nervous system,inflammation,and immune responses were involved.Insulin resistance is one of the main features in metabolic response to stress.Metabolic response to stress was manifested by disorders of energy consumption,such as glucose,lactic acid,lipids,and proteins.The decrease in fat-free body mass and cell mass,relative excess of adipose tissues,and increased extracellular fluid volumes were also involved.Therapeutic interventions,including hormone supplementation,enhanced protein intake,and early mobilization,are considered for prevention and therapy of metabolic response to stress.The review aims to summarize the pathophysiological mechanisms,clinical consequences,and therapeutic implications of metabolic response to stress in critical illness.
