Allee effect in leukemia
10.3760/cma.j.issn.1009-9921.2016.04.002
- VernacularTitle:白血病中的Allee效应
- Author:
Kefu WU
;
Guoguang ZHENG
;
Xiaotong MA
;
Yuhua SONG
- Publication Type:Journal Article
- Keywords:
Leukemia;
Minimal residual disease;
Allee effect;
Evolutionary medicine
- From:
Journal of Leukemia & Lymphoma
2016;25(4):199-202
- CountryChina
- Language:Chinese
-
Abstract:
Allee effect is a phenomenon in ecology characterized by a correlation between population size or density and the mean individual fitness of population or species.It is consistent with density dependent phenomenon in biomedical field.Recently,Allee effect has been studied by theoretical biologist in detail for oncology biological research.Leukemia cells,which reside in organic microenvironment,show an obvious Allee effect.The authors compared Allee effect with density dependent growth of leukemia cells based on their work experience and literature data.No principle distinction was found between these two terms.In this paper,Allee effect in leukemia cell culture and leukemia,especially in minimal residual disease,will be discussed in the view of ecology.The association between Allee effect and leukemogenesis and relapse dynamics will also be explored in the future research.
