Improvement of in Vitro Dissolution Rate of Daidzein by Solid Dispersion Technology
10.3870/j.issn.1004-0781.2016.07.023
- VernacularTitle:应用固体分散技术提高黄豆苷元溶出速率?
- Author:
Xiaofang LI
;
Ping JIANG
;
Bohong GUO
- Publication Type:Journal Article
- Keywords:
Daidzein;
Polyvinyl pyrrolidone;
Solid dispersion;
Dissolution rate
- From:
Herald of Medicine
2016;35(7):769-772
- CountryChina
- Language:Chinese
-
Abstract:
Objective Daidzein solid dispersions were prepared by solid dispersion technology to improve in vitro dissolution rate. Methods Daidzein solid dispersions were prepared by solvent method using polyvinyl pyrrolidone K30 ( PVP K30) as carrier.The in vitro dissolution characteristics of solid dispersions were evaluated,and the properties were detected by IR and XRD. Results The dissolution rates of different mass ratio of daidzein-PVP solid dispersion were significantly improved compared with that of daidzein API.The cumulative dissolution of solid dispersion with mass ratio of 1∶6 within 30 minutes was up to 87.8%,equivalent to six times of API. The in vitro drug release kinetics were fitted mathematically to Korsemeyer-Peppas model. Conclusion Solid dispersion with PVP K30 as carrier could significantly improve dissolution rate of daidzein.
