Effects of Ulinastatin on Perioperative Inflammatory Response During Cardiopulmonary Bypass:A Systematic Review

VernacularTitle:乌司他丁改善体外循环术患者围手术期炎性反应的系统评价
Author: Shuwei SHEN ; Zhongyuan XIA ; Rong CHEN ; Bo ZHAO ; Yan LENG ; Min LIU
Publication Type:Journal Article
Keywords: Ulinastatin; Cardiopulmonary bypass surgery; Perioperative
From: Herald of Medicine 2016;35(7):789-792
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effects of ulinastatin on perioperative inflammatory response during cardiopulmonary bypass. Methods Comprehensive search of PubMed,EMbase,the Cochrane Library,CECDB,CQVIP,CNKI databases was conducted for randomized controlled trials(RCTs) published from January 1994 to June 2014.The included studies were evaluated strictly and the extracted data were analyzed by RevMan 5.2. Results A total of 7 RCTs including 335 patients were included,and 154 patients were in the experimental group,while 181 patients were in the control group.In the experimental group, patients were given Ulinastatin during surgery. System evaluation results show that, the concentration of TNF-α [ SMD (95%CI) were -3.48(-4.64,-2.31)] and IL-6 [SMD(95%CI) were -3.04(-4.54,-1.54)] in experimental group at 1 h after weaning from CPB were significantly lower than those in control group. Conclusion Ulinastatin used perioperatively in cardiopulmonary bypass can significantly reduce postoperative inflammation.