Developing high quality chemical probes targeting ubiquitin-specific proteases
10.3867/j.issn.1000-3002.2016.06.001
- VernacularTitle:开发针对泛素特异性蛋白酶的高质量化学探针
- Author:
Yufeng TONG
- Publication Type:Journal Article
- Keywords:
chemical probes;
drug discovery;
small molecule inhibitors;
ubiquitin-specific proteases
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(6):611-619
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitin-specific proteases (USPs) regulate the deconjugation of ubiquitin tag from substrate proteins. Dysregulation of USPs has been linked to many diseases. Despite extensive efforts by academia and industry,high quality chemical molecules targeting the USPs family of ubiquitin enzymes are still scarce. In this commentary,I propose the criteria of a high quality chemical probe and the strategies to target USPs.
