Effects of RLMF and RLMP on Expression of TRPV5 in IgA Nephropathy Rat Renal Tissue
10.3870/j.issn.1004-0781.2016.07.005
- VernacularTitle:金樱子黄酮与金樱子多糖对TRP V5在IgA肾病肾脏组织中表达的影响?
- Author:
Shanggui SU
;
Yanjun HUANG
;
Yongqi HUANG
;
Guangxiu LUO
;
Shouyin ZHANG
;
Yulan WEI
;
Qingmei ZHANG
- Publication Type:Journal Article
- Keywords:
Laevigata Michx Flavoid;
Rosa laevigata Michx Polysaccharose;
Nephropathy,IgA;
TRPV5
- From:
Herald of Medicine
2016;35(7):702-705
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Rosa Laevigata Michx Flavoid( RLMF) and Rosa laevigata Michx Polysaccharose (RLMP) on expression of TRPV5 in IgA Nephropathy (IgAN) rat renal tissue. Methods Forty Sprague-Dawley rats were randomly assigned to four groups.The rat model of IgA nephropathy was induced by intragastric administration of bovine serumalbumin and injections of LPS and CC14.Eight weeks later,the rats with IgAN were treated with RLMF or RLMP (4 weeks), or normal saline.Rats was sacrificed at thirteenth weeks, and RNA was extracted from the kidney.Expression of TRPV5 in tubulointerstitial tissues were analyzed by fluorescent quantitative RT-PCR. Results After RFLP intervention,the expression levels of TRPV5 were markedly increased (P<0.01) than model control group,while decreased (P<0.05) than normal control group but had no significance with model control group after RFLF intervention. Conclusion TRPV5 expression is decreased in IgAN,and RLMP can adjust TRPV5 expression and improve renal function of IgAN.
