Nanoparticle-based Combination Therapies for Cancer Treatment
10.3870/j.issn.1004-0781.2016.07.019
- VernacularTitle:纳米给药系统的抗肿瘤药物联合治疗策略?
- Author:
Peng YE
;
Wendian ZHANG
;
Tan YANG
;
Yongkang GAI
;
Guangya XIANG
- Publication Type:Journal Article
- Keywords:
Nanoparticle drug delivery;
Drug combination;
Cancer treatment;
Multiple-drug resistance;
Synergistic action
- From:
Herald of Medicine
2016;35(7):752-757
- CountryChina
- Language:Chinese
-
Abstract:
Combination chemotherapy and nanoparticle drug delivery are two promising strategies in cancer treatment. The use of multiple therapeutic agents in combination provides synergistic effects among different drugs against cancer cells and suppresses drug resistance through distinct mechanisms of action.Nanocarriers can improve anti-tumor effects of drugs and reduce systemic toxicity through delivering drugs into the tumor tissue specially. Recently, many studies are aiming to encapsulate multiple agents into nanocarriers to optimize the anti-tumor effects. In the present review, the recent advances of nanoparticle platforms applied with co-delivering two or more drugs were summarized and the various combination strategies based on nanoparticles in oncology were discussed.
