Expression and clinical significance of HGF and C-Met in cholangiocarcinoma

VernacularTitle:HGF 蛋白与 C-M et 蛋白在胆管癌中的表达及临床意义
Author: Jin WANG ; Yijie ZHAO ; Guangbin CUI ; Peizhong SHANG
Publication Type:Journal Article
Keywords: cholangiocarcinoma; hepatocyte growth factor; C-Met; clinical and pathological features
From: Chongqing Medicine 2016;45(17):2362-2364
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and clinical significance of HGF and C-Met in cholangiocarcinoma .Meth-ods The levels of HGF and C-Met were measured by ELISA ,the expression of HGF and C-Met in cholangiocarcinoma and health control was detected by immunohistochemistry .Results The preoperative levels of HGF and C-Met in cholangiocarcinoma were higher than the health control(P< 0 .05) .Compared with the preoperative state ,the levels of HGF and C-Met in cholangiocarcino-ma on the 3rd day after operation did not change significantly .However ,the levels of HGF and C-Met on the postoperative 7th and 10th day decreased obviously .In addition ,the expression of HGF and C-Met in cholangiocarcinoma was 76 .2% ,81 .0% ,respective-ly ,which is higher than that in normal tissue ( P < 0 .01) .Conclusion There is an abnormal expression of HGF and C-Met in cholangiocarcinoma ,which may be related to the incidence and development of cholangiocarcinoma .