Study on Th1/Th2/Th17 balance in atopic dermatitis

VernacularTitle:特应性皮炎Th1／Th2／Th17平衡的研究
Author: Yourang JIANG ; Qingchun DIAO ; Bingjun SHI ; Yinglin WANG ; Kejia XU ; Lin FENG
Publication Type:Journal Article
Keywords: atopic dermatitis; cytokines; Th1 cells; Th2 cells; Th17 cells; flow immunofluorescence technology
From: Chongqing Medicine 2016;45(18):2482-2483
CountryChina
Language:Chinese
Abstract: Objective To research the change rule of peripheral serum Th1/Th2/Th17 balance and relevant cytokines in atopic dermatitis(AD) and to further study its immunologic mechanism .Methods The levels of peripheral serum IFN‐γ,IL‐4 ,IL‐17 ,IL‐21 and IL‐23 in the patients with AD were detected by the flow immunofluorescence technology and the detection results were performed the statistical analysis ,thus the change rule of Th1/Th2/Th17 balance in AD was analyzed .Results The IL‐4 level in peripheral serum of the patients with AD was increased compared with the healthy control group (P<0 .05);the IFN‐γ/IL‐4 and IFN‐γ/IL‐17 in the AD group were significantly decreased compared with the control group (P<0 .01);IL‐17 was positively corre‐lation with SCORAD scores of AD severity (P<0 .05) .Conclusion Th1/Th2 and Th1/Th17 are decreased in the AD course .Th1/Th2/Th17 balance drift may be the important mechanism of AD pathogenesis .