Study on effect of Kuntai Capsule on mice endometrial receptivity
10.3969/j.issn.1671-8348.2016.18.005
- VernacularTitle:坤泰胶囊对小鼠子宫内膜容受性影响的研究
- Author:
Hui WANG
;
Yujie LI
;
Fan CHEN
;
Yan NAN
- Publication Type:Journal Article
- Keywords:
Kuntai Capsule;
endometrial receptivity;
controlled ovarian hyperstimulation;
lysophosphatidic acid receptors 3
- From:
Chongqing Medicine
2016;45(18):2464-2466
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the effect of Kuntai Capsule on mice endometrial receptivity by comparing the lyso‐phospholipids acid receptor‐3(LPAR3) expression in endometrium during mouse embryos implantation period .Methods Ninety 6-8 week old Kunming female mice were randomly divided to three groups :the group A [controlled ovarian hyperstimulation (COH)] ,B (COH+Kuntai Capsule) and C(normal saline control) ,30 cases in each group .The vaginal plug was performed on the next day after mating .Five mice in each group were daily killed on 1 -6 d .The serum estradiol(E2) and progesterone(P) levels were detected .The glands number and the immunohistochemical integrated optical density (IOD) were also determined .Results The levels of serum E2 amd P in the group A and B were higher than those in the group C at the same period (P<0 .05);in the HE staining ,the glands number in the group A was significantly decreased compared with the group B and C (P<0 .05) .The IOD value of LPAR3 on 3 d in the group A was significantly lower than that in the group B and C (P<0 .05) ,while the group B was slightly higher than the group C without statistical difference (P>0 .05) .Conclusion Kuntai Capsule may play the role for improving the endometrial receptivity by improving the normal space‐time expression of LPAR3 .
