Clinical observation of tranexamic acid on chronic subdural hematoma：report of 19 cases

VernacularTitle:氨甲环酸保守治疗慢性硬膜下血肿19例临床观察
Author: Duqiang LIU ; Yong JIANG ; Dingjun LI ; Jian YOU ; Lilei PENG ; Jie ZHOU ; Tangming PENG ; Luotong LIU
Publication Type:Journal Article
Keywords: chronic subdural hematoma; tranexmamic acid; drug therapy
From: Chongqing Medicine 2016;45(17):2340-2342
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect of tranexamic acid (TXA ) in medical treatment of chronic subdural hematoma (CSDH) .Methods A total of 19 patients with CT-confirmed CSDH in our department from Mar 2014 to Aug 2015 received an in-travenous dose of 1g TXA in the first week ,and followed by a maintenance oral dose of 250 mg TXA three times a day for 1 - 5 months (2 .73 ± 1 .05) months .These patients received a follow-up period of 6 - 10 months .Hematoma volume and neurological functions were compared before and after treatment .Results The therapeutic outcome was divided into effectiveness and ineffec-tiveness .Thirteen cases (68 .4% ) were effective ;six cases (31 .6% ) were ineffective .Among them ,three patients (15 .8% ) whose neurological functions deteriorated underwent surgery ,one patient (5 .3% ) who did not show any improvement with initial one month of TXA underwent surgery ,one patient (5 .3% ) stopped the treatment due to the side-effect of drug ,one patient (5 .3% ) lost .Conclusion Results of this preliminary study show that the administration of TXA is effective and safe in treating CSDH .