Correlation of serum level of growth differentiation factor-15 with acute myocardial infarction

VernacularTitle:生长分化因子-15血清水平与急性心肌梗死相关性研究
Author: Donglei LUO ; Jingtao GUO ; Yongjun LI ; Jiang ZHOU ; Zhiguo ZHAO ; Tong LIU ; Lei ZHANG ; Yanchun HOU ; Ling LI
Publication Type:Journal Article
Keywords: acute myocardial infarction; growth differentiation factor-15; enzyme-linked immunosorbent assay
From: Chongqing Medicine 2016;45(18):2491-2493
CountryChina
Language:Chinese
Abstract: Objective To explore the correlation between serum growth differentiation factor‐15(GDF‐15) level and acute myocardial infarction(AMI) to provide a basis for the prognostic evaluation of AMI .Methods Totally 192 Han patients with AMI (AMI group) and non‐coronary heart disease (NCHD ,NCHD group) diagnosed in Chengde Municipal Central Hospital from Sep‐tember 2013 to January 2015 ,were selected and their clinical data were collected .The biochemical markers and serum GDF‐15 level were detected .Results Comparing the AMI group with the NCHD group ,differences in the patients′age ,smoking ,blood glucose (Glu) ,TC ,TG ,LDL‐C levels had statistical significance (P<0 .05);the serum GDF‐15 level in the AMI group was significantly higher than that in the NCHD ;serum GDF‐15 level was positively correlated with TC ,LDL‐C ,hs‐CRP and Glu in the AMI group . Conclusion The increase of serum GDF‐15 level is obviously correlated AMI ,therefore GDF‐15 can serve as an indicator for moni‐toring myocardial infarction .