Efficacy of Ginkgo-Leaf Capsule combined with tripterygium glycoside in treating diabetic nephropathy and its influence on CysC,Hcy and VEGF
10.3969/j.issn.1671-8348.2016.18.020
- VernacularTitle:银杏叶胶囊联合雷公藤多苷治疗DN 疗效和对患者CysC、Hcy及 VEGF的影响
- Author:
Yanjun WANG
;
Jingrong HUANG
- Publication Type:Journal Article
- Keywords:
ginkgo-leaf capsule;
tripterygium glycoside;
diabetic nephropathy;
renal function;
cystatin C;
homocysteine;
vas-cular endothelial growth factor
- From:
Chongqing Medicine
2016;45(18):2513-2515
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of Ginkgo‐Leaf Capsule combined with tripterygium glycoside in the treat‐ment of diabetic nephropathy(DN) and its influence on CysC ,Hcy and VEGF .Methods Eighty patients with DN treated in our hospital from January 2013 to April 2015 were selected as research subjects and equally divided into the control group and the ob‐servation group according to the random number table ,40 cases in each group .Besides the conventional Western medicine treat‐ment ,the control group was given tripterygium glycoside ,while the observation group was given Kinkgo‐Leaf Capsule combined with tripterygium glycoside .The treatment course was 3 months .Then ,the curative efficacy ,indices of renal function ,levels of Cy‐sC ,Hcy and vascular endothelial growth factor(VEGF) ,and occurrence situation of adverse reactions were compared between the two groups .Results The total therapeutic efficacy rate in the observation group and the control group was 92 .50% and 80 .00%respectively without statistically significant difference (P>0 .05) .In the comparison with the control group after treatment ,the re‐nal function indices of serum creatinine ,urea nitrogen ,24 h urinary protein ,level of serum CysC ,Hcy and VEGF in the observation group were statistically decreased (P< 0 .05) .During the treatment process ,no severe adverse reactions occurred in the two groups .The incidence rate of adverse reactions in the observation group and the control group was 17 .5% and 12 .5% respectively without statistical difference (P>0 .05) .Conclusion Ginkgo‐Leaf Capsule combined with tripterygium glycoside is effective and reliable for treating DN ,which can significantly improve the renal function ,reduces the level of serum CysC ,Hcy and VEGF .
