The clinical values of dexmedetomidine in general anesthetic for laparoscopic cholecystectomy
10.3760/cma.j.issn.1008-6706.2016.15.036
- VernacularTitle:右美托咪定在腹腔镜胆囊切除术麻醉中的应用价值
- Author:
Bo LI
;
Yujie ZHOU
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
General Anesthetic;
Laparoscopic Cholecystectomy;
Postoperative complication
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(15):2369-2372
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical values of dexmedetomidine in general anesthetic for laparo-scopic cholecystectomy.Methods One hundred patients admitted to our center with cholelithes were prospectively studied.According to the principle of completely random digital table,all patients were randomly signed to dexmedeto-midine group or control group.The primary outcomes were hemodynamic changes and postoperative complications. Results There was no significant differences at t0,t1,t2,t3,t4 and t5 in mean arterial pressure (P >0.05).There was no significant difference in heart rate at t0 (P =0.503),however,compared with the control group,patients in the dexmedetomidine group got a significant reduction in t1,t2,t3,t4 and t5 in heart rate(all P <0.05).Compared with the control group,the operation time of the dexmedetomidine group was significantly shorten[(1 18.52 ±15.42)min vs.(127.24 ±19.14)min,t = -5.673,P =0.021 ],the rate of movement of the center of the operation was significantly decreased (36% vs.64%,χ2 =7.840,P <0.001),the incidence rate decreased significantly (0% vs. 10%,χ2 =5.263,P =0.022).There was no difference between the two groups in intra -operative bleeding volume, hypertension,hypotension,tachycardia,postoperative drainage volume,postoperative bleeding,infection and vomiting (all P >0.05 ).Conclusion Dexmedetomidine contributed to maintaining the hemodynamic stable in general anesthetic for laparoscopic cholecystectomy,and reducing the rate of shivering.
