Research progress on integrated molecular pathological classification of diffuse lower-grade gliomas
10.3969/j.issn.1000-8179.2016.12.340
- VernacularTitle:弥漫性较低级别胶质瘤的整合性分子病理分型研究进展
- Author:
Zhaohui LI
;
Zhigang GUO
;
Qingwei LI
- Publication Type:Journal Article
- Keywords:
glioma;
molecular pathology;
IDH;
ATRX;
TERT
- From:
Chinese Journal of Clinical Oncology
2016;43(12):541-544
- CountryChina
- Language:Chinese
-
Abstract:
Diffuse lower-grade glioma is a diversified group of infiltrative brain tumors comprising WHO grades II and III astrocytomas, oligodendrogliomas, and mixed oligoastrocytomas. These tumors exhibit a wide range of clinical heterogeneity;thus, histopathological classification does not adequately predict clinical outcomes. In recent years, a number of molecular markers closely related to the clini-cal features and prognosis of gliomas have been discovered. These molecular markers include isocitrate dehydrogenase (IDH) muta-tion, chromosome 1p/19q codeletion, ATRX mutation, TERT promoter mutation, and MGMT promoter methylation. Furthermore, nu-merous studies focusing on the integrated molecular classification of diffuse lower-grade gliomas combined with these molecular markers have been conducted. Results indicate that integrated molecular pathological classification can improve the diagnostic and prognostic accuracy and facilitate therapeutic formulation. This paper reviews the research progress on integrated molecular classifica-tion of diffuse lower-grade gliomas.
