Molecular basis and precision medicine for interactions of genetic and environmental risk factors in esophageal cancer
10.3969/j.issn.1000-8179.2016.12.028
- VernacularTitle:食管癌环境和遗传危险因素交互作用的分子基础和精准预防
- Author:
Lidong WANG
;
Xin SONG
;
Xueke ZHAO
;
Minjie WU
;
Fuyou ZHOU
- Publication Type:Journal Article
- Keywords:
esophageal squamous cell carcinoma;
high susceptibility gene;
precision medicine;
evionment;
genetic factor;
interaction
- From:
Chinese Journal of Clinical Oncology
2016;43(12):515-520
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal cancer is a unique malignant disease in China. A fundamental difference exists between the Chinese population and the western population on esophageal cancer in terms of epidemiology, histogenesis, and carcinogenic risk factors. Therefore, ap-plying the western academic achievements to Chinese is difficult. Thus, Chinese scientists have the responsibility to conquer esopha-geal cancer in China. This article reviews the progress of esophageal cancer focused on the molecular mechanism for interactions of ge-netic and environmental risk factors and human esophageal multistage carcinogenesis.
