Renal vascular damage and the expression of miR-145 in lupus nephritis
10.3969/j.issn.1000-3606.2016.06.002
- VernacularTitle:狼疮性肾炎肾血管损害和miR-145的表达
- Author:
Hua LIU
;
Xiaojie HE
;
Zhilan HU
- Publication Type:Journal Article
- Keywords:
lupus nephritis;
renal vascular damage;
miR-145
- From:
Journal of Clinical Pediatrics
2016;34(6):406-410
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate renal vascular damage (RVLs) and detect the expression of miR-145 in children with lupus nephritis (LN).Methods Clinical data of 41 cases of LN diagnosed by renal biopsy from the children with systemic lupus erythematosus (SLE) were collected. Glomerular damage score and RVLs were evaluated. The children were divided into groups according to RVLs score and pathological pattern. In situ hybridization was performed to detect the expression of miR-145 in kidney blood vessel. Differences in RVLs, miR-145 expression in the renal blood vessels and glomerular damage score were observed among the groups with different renal pathological pattern. Differences in clinical parameters, glomerular damage score and miR-145 expression in the renal blood vessels were investigated among groups with different RVLs. Results Among the groups with different pathological pattern, there was no difference in RVLs (P>?0.05) while signiifcant different were found in the expression of miR-145 and glomerular damage score (P??0.05) while a statistical different was found in the expression of miR-145 (P?
