The relationships of hyperuricemia with clinical and Oxford classiifcations in children with IgA nephropathy
10.3969/j.issn.1000-3606.2016.06.003
- VernacularTitle:儿童IgA肾病高尿酸血症与临床及牛津分型的关系
- Author:
Yang LIU
;
Jinfeng WEI
;
Xuemei ZHOU
;
Changchun LI
;
Zhihao ZHANG
;
Fagui HE
- Publication Type:Journal Article
- Keywords:
IgA nephropathy;
hyperuricemia;
Oxford classiifcation;
child
- From:
Journal of Clinical Pediatrics
2016;34(6):411-413
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationships of hyperuricemia with clinical and Oxford classifications in children with IgA nephropathy.Methods Clinical data of 213 children with IgA nephropathy were retrospective analyzed. According to the levels of blood uric acid, these children were divided into two groups, hyperuricemia group (n?=?51) and normal uric acid group (n?=?162). Differences of clinical index and Oxford classiifcation between the two groups were observed. Results The 24 h urinary protein, level of serum creatinine, glomerular ifltration rate (eGFR) in hyperuricemia group were signiifcantly higher than those in normal group (P all?0.05). Oxford classiifcation showed that the degree of mesangial cell proliferation (M1) and renal tubular atrophy/interstitial ifbrosis (T1-2) in hyperuricemia group were more serious than in normal uric acid group (P all?0.01).Conclusions Children with IgA nephropathy combined with hyperuricemia were worse in clinical index and pathological manifestations. Increased serum uric acid may be one of the important factors that contribute to poor prognosis of children with IgA nephropathy.