Drug-induced hypersensitivity syndrome in children：a case report

VernacularTitle:儿童药物超敏反应综合征1例报告
Author: Yan ZHAO ; Ying HUANG
Publication Type:Journal Article
Keywords: drug-induced hypersensitivity syndrome; vancomycin; child
From: Journal of Clinical Pediatrics 2016;34(6):457-460
CountryChina
Language:Chinese
Abstract: Objective To analyze the diagnose and treatment of drug-induced hypersensitivity syndrome (DIHS) in children.MethodsThe clinical data from one case of highly suspected DIHS were retrospectively analyzed. The related literatures were reviewed.ResultsA 22-month-old male child with severe pneumonia, after treated with vancomycin, suffered with high fever and skin rash combined with hepatic lesion and hematological system disorder. After withdrawal of vancomycin and then treatment with the combination of high-dose methylprednisolone and intravenous immunoglobulin, the clinical symptoms were gradually relieved in 24 hours. The child was improved and discharged on 17th day.ConclusionThe child has the characteristics of DIHS which is highly suspected to be caused by vancomycin.