Detection of peripheral NGAL and MMP9 levels and its clinical significance in primary hepatic carcinoma
10.3969/j.issn.1671-8348.2016.17.017
- VernacularTitle:NGAL 及 MMP9在原发性肝癌患者血清中表达及意义
- Author:
Chengjia TANG
;
Tianwu YU
- Publication Type:Journal Article
- Keywords:
primary hepatic carcinoma;
NGAL;
matrix metalloproteinase 9
- From:
Chongqing Medicine
2016;45(17):2357-2359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of matrix metalloproteinase 9(MMP9) and neutrophil gelatinase associated li-pocalin(NGAL) in primary hepatic carcinoma and its clinical significance .Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum level of MMP9 and NGAL in 47 patients with primary hepatic carcinoma and 19 healthy controls .The association between serum MMP9 and NGAL levels with the clinicopathological features of hepatic carcinoma were evaluated .ROC curves were used to analyze the influence of MMP9 and NGAL on the diagnostic value .Kaplan-Meier method was used to evaluate the relationship between the expressions of NGAL and MM P9 and the prognosis of patients with HCC .Results Serum MMP9 and NGAL levels in hepatic carcinoma patients are significantly higher compared with normal controls (P ≤ 0 .05) .The serum level of MMP9 and NGAL in primary hepatic carcinoma was positively correlated with TNM stage (P≤ 0 .05) .The sensitivity and specifici-ty of MMP9 and NGAL for primary hepatic carcinoma were 70 .2% and 83 .0% .The sensitivity of the joint detection were 94 .9% . Kaplan Meier survival curves showed that cumulative survival rates of patients with positive expression of NGAL were significantly lower than those of patients with negative expression .Conclusion MM P9 and NGAL might play an important role in gastric cancer generation and development .Monitoring of serum MMP9 and NGAL levels might be helpful for diagnosis and evaluation of progno-sis for primary hepatic carcinoma .
