The clinical curative effect and prognosis of clopidogrel combined with enteric -coated aspirin in the treatment of unstable angina pectoris of coronary heart disease
10.3760/cma.j.issn.1008-6706.2016.14.018
- VernacularTitle:阿司匹林肠溶片联合氯吡格雷治疗不稳定型心绞痛的临床疗效及预后观察
- Author:
Yanlin LIU
;
Ning ZHANG
;
Ying WANG
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Angina pectoris;
Enteric -coated aspirin;
Clopidogrel;
Cura-tive effect
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(14):2145-2148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore and analyze the clinical curative effect and prognosis of enteric -coated aspirin combined with clopidogrel in the treatment of unstable angina pectoris of coronary heart disease.Methods 84 patients with unstable coronary heart disease angina pectoris were selected in the research,and they were divided into regular treatment group and combination group,42 cases in each group.The patients in conventional treatment group were given enteric -coated aspirin therapy,and the combined treatment group were given clopidogrel on the basis of routine treatment.The myocardial enzymology indexes of 24h before and after drug treatment,electrocardio-gram (ECG)recovery,curative effect and adverse reaction were compared between the two groups.Results After treatment,the myocardial enzymology indexes of the combined treatment group (AST,CK -MB,cTnT,cTnI)had sig-nificant differences compared with the general treatment group (t =3.98,P <0.05,t =0.05,P <0.05,t =0.05,P <0.05,t =0.05,P <0.05).After treatment,the ECG total recovery rate of the combination group increased obviously compared with the conventional treatment group,the difference between the two groups was significant (χ2 =5.49, P <0.05).The total effective rate of the combined treatment group increased obviously compared with the conventional treatment group,the difference between the two groups was significant (90.5% vs 64.3%,χ2 =4.48,P <0.05).The incidence rate of adverse reactions had no obvious difference between the two groups (83.3% vs 66.7%,χ2 =2.88, P >0.05).Conclusion Drug combination therapy in the treatment of unstable type of coronary heart disease angina pectoris can synergistically improve clinical symptoms and physical fitness,improve patients'quality of life,it is safe and reliable,which is worth popularization and application widely.
