Progress in pathogenic mechanism of hypervirulent Klebsiella pneumoniae
10.3760/cma.j.issn.0254-5101.2016.06.013
- VernacularTitle:高毒力肺炎克雷伯菌的致病机制研究进展
- Author:
Lifeng WANG
;
Dingxia SHEN
- Publication Type:Journal Article
- Keywords:
Klebsiella pneumoniae;
Virulent;
Liver abscess;
Immunity
- From:
Chinese Journal of Microbiology and Immunology
2016;36(6):468-471
- CountryChina
- Language:Chinese
-
Abstract:
Hypervirulent Klebsiella pneumoniae ( hvKP) mainly infects healthy people and causes serious infections, such as liver abscess, meningitis, necrotizing fasciitis, endophthalmitis and severe pneu-monia. Studies have shown that hvKP is more virulent than classic Klebsiella pneumoniae characterized by ex-pressing more capsular polysaccharide and carrying the virulence factors including magA, rmpA and iron ac-quisition molecules. The greater survival and anti-phagocytosis abilities of hvKP strains contribute to the spread and metastasis of hvKP infection. This review describes the virulence factors, colonization and infec-tion of hvKP as well as the host immunity to hvKP.
