Meta Analysis of Relationship between Helicobacter pylori Infection and Autoimmune Thyroid Diseases
10.12007/j.issn.0258-4646.2016.08.015
- VernacularTitle:幽门螺杆菌感染与自身免疫性甲状腺病关系的meta分析
- Author:
Chunyan YUE
;
Caizhe YANG
;
Yin YANG
;
Chaoyang LIU
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
autoimmune thyroid diseases;
meta analysis
- From:
Journal of China Medical University
2016;45(8):733-738
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between Helicobacter pylori(H. pylori) infection and Autoimmune thyroid diseases (ATDs). Methods The literatures on the association of H. pylori with ATDs were retrieved by searching databases from the inception of each da?tabase to October 2015. Data extraction and quality assessment were completed by two authors. Meta analysis was performed using RevMan 5.3 software,calculating the odds ratio and 95%confidence interval. Results Twelve papers were included for the meta?analysis. The total sample size was 1 615,with 918 cases and 697 controls,respectively. Compared with the controls,H.pyloriinfection significantly increased the risk of auto?immune thyroid diseases development with a pooled of[OR=1.86,95%CI(1.18,2.94)]. H.Pylori?CagA infection significantly increased the risk of autoimmune thyroid diseases development with a pooled of[OR=2.66,95%CI(1.61,4.41)]. H. pylori infection is associated with Graves dis?ease[OR=3.37,95%CI(1.90?5.97)]and Hashimoto′s thyroiditis[OR=1.83,95%CI(1.22,2.76)]. The results of publication bias and sensitivi?ty analysis confirmed the reliability and stability of this meta analysis. Conclusion H. pylori infection may be associated with an increased risk of developing the autoimmune thyroid diseases.
