Effect of Transcutaneous Electrical Stimulation on Jiaji Acupoint on Expression of Glial Fibrillary Acidic Protein and Inflammation in Rats after Spinal Cord Injury
10.3969/j.issn.1006-9771.2016.06.008
- VernacularTitle:经皮电刺激夹脊穴对大鼠脊髓损伤后神经胶质纤维酸性蛋白及炎症反应的影响
- Author:
Chunmei CHEN
- Publication Type:Journal Article
- Keywords:
spinal cord injury;
transcutaneous electrical stimulation;
glial fibrillary acidic protein;
nuclear factor kappa B;
interleu-kin-6;
rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(6):660-666
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of transcutaneous electrical stimulationon on Jiaji acupoint (Ex-B 05) on the expression of glial fibrillary acidic protein (GFAP), nuclear factor kappa B (NF-κB) and interleukin-6 (IL-6) in rats with spinal cord injury (SCI). Meth-ods Ninety healthy adult Sprague-Dawley rats were randomly divided into normal group (group A, n=30), transcutaneous electrical stimula-tion treatment group (group B, n=30) and control group (group C, n=30). Allen's method was used to establish the model of acute SCI in T9. All of them were assessed with Basso-Beattie-Bresnahan (BBB) scale and Slanting Board Test, and the expression of GFAP, NF-κB and IL-6 of the spinal cord were detected with immunohistochemistry one, three and seven days after operation. Results The results of BBB scale and Slanting Board Test were better in group B than in group C three and seven days after SCI (t>3.349, P<0.01). The expression of GFAP, NF-κB and IL-6 was lower in group B than in group C at all the time points after SCI (t>20.815, P<0.001). Conclusion Transcutane-ous electrical stimulation can inhibit the inflammation and the expression of GFAP in spinal cord after SCI, and improve the motor function in rats after SCI.
