Efficacy observation of pemetrexed treatment in advanced non -squamous non -small cell lung cancer who failed first line therapy

VernacularTitle:培美曲塞治疗一线失败的晚期非鳞非小细胞肺癌的疗效观察
Author: Juan NING ; Guihua GAO ; Lijuan HU ; Jianping WANG
Publication Type:Journal Article
Keywords: Cancer,Non -small cell lung; Pemetrexed; Pharmacotherapy
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(15):2339-2342
CountryChina
Language:Chinese
Abstract: Objective To observe the clinical effects of pemetrexed alone or pemetrexed combined with platinum in the treatment of advanced non -squamous non -small cell lung cancer who failed first line therapy. Methods 34 patients with advanced NSCLC who had failed to previous chemotherapy and all of these patients had been confirmed with pathology or cytology.Pemetrexed monotherapy group included 14 cases and pemetrexed plus platinum group included 20 cases.21 days as one cycle.All patients who received 2 or more cycles could be evaluated. Results No complete response (CR)occurred.There were 3 cases of partial response (PR),15 cases of stable disease(SD)and 16 cases of progressive disease(PD)in the 34 patients.The disease control rate was 52.9%(18 /34).The median progressive free survival was 2.7 months.The major toxic reaction included leucopenia,anemia and gastrointestinal response.Conclusion Pemetrexed or pemetrexed combined with platinum can prolong the survival time of some patients of non -squamous non -small cell lung cancer who failed first line therapy.The toxic effects can be tolerated.