The clinical and pathological features of capillary proliferative purpura nephritis in 19 children
10.3969/j.issn.1000-3606.2016.06.004
- VernacularTitle:儿童毛细血管内增生性紫癜性肾炎19例临床及病理分析
- Author:
Chundong SONG
;
Ying DING
;
Zonggang ZHAI
;
Wensheng ZHAI
;
Xianqing REN
;
Qingyin GUO
;
Xia ZHANG
;
Meng YANG
;
Jian ZHANG
- Publication Type:Journal Article
- Keywords:
anaphylactic purpura nephritis;
endocapillary proliferative;
child
- From:
Journal of Clinical Pediatrics
2016;34(6):414-417
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical and pathological features, treatment, and prognosis of capillary proliferative purpura nephritis (DEP-HSPN) in children.MethodsThe clinical data of 19 children diagnosed with DEP-HSPN were retrospectively analysis. Fifty-five children diagnosed with HSPN by renal biopsy were randomly selected as control group. ResultsThe average age was 10.6±2.6 years old, and the average course of disease were 19.4±7.4 days before renal biopsy in 19 children with DEP-HSPN (14 males and 5 females) who make up 3.92% of anaphylactic purpura nephritis children conifrmed by renal biopsy in the same period. In these 19 children, there were 10 cases having nephrotic syndrome and 9 case having hematuria and proteinuria type, all of whom were received immunosuppressive therapy. Finally, 14 cases achieved completely remission and 5 cases had partly remission. All of their classiifcations of renal pathology wereⅢb levels, accompanied with 6.38% to 36.36% of crescents. Compared with 55 age and sex matched children with renal pathology classiifcation ofⅢb, the DEP-HSPN children had shorter disease course, higher level of proteinuria, and lower pathological score of chronic renal injury (P all?
