Effects of bisphosphonates on the expression of Bcl-2, Bax and Caspase-3 in condylar cartilage of osteoporosis rats
10.3969/j.issn.2095-4344.2016.27.003
- VernacularTitle:利塞膦酸钠干预骨质疏松模型大鼠髁突软骨Bcl-2、Bax及Caspase3的表达
- Author:
Qi ZHOU
;
Li WEI
;
Liting JIANG
;
Ning LI
;
Yiming GAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(27):3970-3976
- CountryChina
- Language:Chinese
-
Abstract:
RESULTS AND CONCLUSION:(1)The number of apoptotic cels in rat condylar cartilage and subcondylar region: the sham operation group < the treatment group < the model group (alP< 0.05). (2)Expression of Bcl-2: The trend of the model group was lower than that in the sham operation group, although there was no statisticaly significant difference between the two groups; Bcl-2 expression in the treatment group was statisticaly higher compared to the model group (P< 0.05).(3)Expression of Bax and Caspase-3: The expression levels of Bax and Caspase-3 were higher in the model group than in the sham operation group (alP< 0.05), while Bax and Caspase-3 expression was lower in the treatment group than that in the model group (alP< 0.05). The results suggested that bisphophonates can regulate apoptosis in condylar cartilage from osteoporosis rats by changing the expression of Bcl-2, Bax and Caspase-3.
