Regulation of osteoarthritis hypoxia-inducible factor-2alpharegulatory mechanism and application prospect
10.3969/j.issn.2095-4344.2016.24.021
- VernacularTitle:低氧诱导因子2α调控骨关节炎：机制研究与转化应用
- Author:
Chao YANG
;
Lei ZHANG
;
Liwu ZHOU
;
Jianning ZHAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(24):3634-3641
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Hypoxia inducible factor-2 α(HIF-2α)is one of the key regulators in articular cartilage degeneration and endochondral osteogenesis. OBJECTIVE:To review the regulatory mechanism and application development of HIF-2α in articular cartilage degeneration. METHODS:A computer-based retrieval of PubMed and CNKI databases was performedforrelevant literatures published from January 1990 to October 2015 ,using the key words of “hypoxia inducible factor-2α; osteoarthritis; cartilage” in Chinese and English, respectively. RESULTS AND CONCLUSION:HIF-2α is a transcription factor encoded by the Epas1 gene, which is one of the key regulators in articular cartilage degeneration and endochondral osteogenesis by directly regulating the expressions of various catabolic genes to strengthen cartilage destruction in osteoarthritis. It has been reported that HIF-2α acts on the chondrocytes by regulating the expressions of Wnt/β-Catenin, nuclear factor-κ B, and interleukin-6.
