Clinical research of the effects of miRNA and hypersensitive C-reactive protein on non-targeted vessels in patients with acute coronary syndromes after percutaneous coronary intervention procedure
10.3760/cma.j.issn.1008-6315.2016.07.005
- VernacularTitle:血浆miRNA及超敏C反应蛋白对急性冠状动脉综合征P CI术后非靶病变进展影响的临床研究
- Author:
Lili YANG
;
Yu ZHAO
;
Li WANG
;
Xiaodan YAN
;
Yaqin DI
;
Baizan TANG
;
Haifeng SHAO
- Publication Type:Journal Article
- Keywords:
Hypersensitive C-reactive protein;
miRNA;
Acute coronary syndrome;
Percutaneous coronary intervention;
Non-target-lesion
- From:
Clinical Medicine of China
2016;32(7):593-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of miRNA and hypersensitive C?reactive protein ( hs?CRP ) on non?targeted vessels in patients with acute coronary syndromes ( ACS ) after percutaneous coronary intervention( PCI) procedure. Methods The serum samples were collected from 217 cases ACS patients to detect the level of miRNA?14?5P and hs?CRP during admission and follow?up periods.All patients underwentPCI with stent implantation and coronary angiography,and CAG was performed at the time of 12?month follow?up.According to CAG results,the patients were divided into non target lesion progression group(progressiongroup) with 76 cases and non target lesion no progression group(no progression group) with 141 cases.Results The expression level of hs?CRP was significantly higher in progression group than the no progression group((1.65±0.18) mg/L vs.(1.52±0.37) mg/L,t = 3.478,P<0.001).The expression level of miRNA?142?5Pwas higher in progression group than the no progression group(27.12±2.11 vs.34.73±2.67,t = 23.035,P<0.001).Multi?factor regression analysis indicated that high expression levels of hs?CR and miRNA?142?5Pduring admission were the predictors of advance of non?targeted vessels patients(OR = 3.496,95%CI 2.046-5.981,P =0.001;OR =1.208,95%CI 1.073-1.361,P =0.002).Conclusion The serum level of hs?CRP andmiRNA?142?5P can predict non?targeted vessels in patients with ACS after PCI.
