Expression and significance of CD44v6 in lung squamous cell carcinoma tissues before and after neoadjuvant radiotherapy
10.3760/cma.j.issn.1008-6315.2016.07.016
- VernacularTitle:CD44 v6在新辅助放疗前后肺鳞状细胞癌组织中的表达和意义
- Author:
Huabing WEN
;
Ruyuan GUO
;
Jidong ZHANG
;
Li LI
- Publication Type:Journal Article
- Keywords:
Neoadjuvant radiotherapy;
Lung squamous cell carcinoma;
CD44v6;
Expression
- From:
Clinical Medicine of China
2016;32(7):633-636
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and clinical significance of neoadjuvant radiotherapy for the expression of CD44v6 in lung squamous cell carcinoma tissues. Methods Fifty cases lung squamous cell carcinoma patients confirmed by aspiration biopsy from May 2013 to January 2015 were collected in Yangquan Coal Mine Group Genernal Hospital,including 20 cases of patients with stageⅢA were treated with neoadjuvant radiotherapy before surgery,and then performed surgery after neoadjuvant therapy. The expression of CD44v6 was detected by immunohistochemistry. The correlation between CD44v6 and clinicopathological features was analyzed by chi?square test. Results Immunohistochemical staining of CD44v6 was performed in tumor tissue of puncture biopsy, the positive rate expression of CD44v6 was 72%( 36/50 ) , it was associated with lymphatic metastasis(χ2 =3. 964, P=0. 046 ) and advanced TNM stage (Ⅲ+Ⅳstage ) (χ2 =4. 276, P=0. 039 ) . The positive expression of CD44v6 protein in tumor tissue was significantly decreased in 20 patients with neoadjuvant radiotherapy compared with before radiotherapy(7. 23±1. 45 vs. 11. 42±1. 31,t=2. 524,P=0. 025). Conclusion Positive expression of CD44v6 in human lung squamous cell carcinoma is related to the malignant clinicopathological features. Neoadjuvant radiotherapy before operation may improve prognosis via down?regulating CD44v6 expression.
