Change and significance of serum brain-derived neurotrophic factor level in neonatal hyperbilirubinemia
10.3760/cma.j.issn.1008-6315.2016.07.022
- VernacularTitle:新生儿高胆红素血症血清脑源性神经营养因子的变化及意义
- Author:
Zhifang DU
;
Suyan YANG
;
Fang LIU
;
Zhaoxia LUY
;
Chunfeng ZHOU
;
Zhimei GUO
- Publication Type:Journal Article
- Keywords:
Brain-derived neurotrophic factor;
Hyperbilirubinemia;
Newborn;
Magnetic resonance imaging
- From:
Clinical Medicine of China
2016;32(7):654-656
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of the serum brain?derived neurotrophic factor( BDNF) level in severe neonatal hyperbilirubinemia. Methods One hundred and twenty term and birth weight>2500 g infants admitted to the Neonatal Intensive Care Unit of Bethune nternational Peace Hospital of People Liberation Army were divided into severe hyperbilirubinemia group and control group according to their total bilirubin concentration. Total bilirubin( TBIL) concentration,BDNF and albumin in serum were determined in two groups. In addition, craniocerebral MRI was performed in severe neonatal hyperbilirubinemia before discharge. The correlation of the BDNF, TBIL, B/A, MRI results between severe hyperbilirubinemia group and control group were compared. Results The serum BDNF levels in severe hyperbilirubinemia group was ( 8. 84 ±3. 26) μg/L,significantly higher than that in control group((6. 24±1. 71) μg/L,t=3. 88,P<0. 05). In severe hyperbilirubinemia group,BDNF level was positively correlated with B/A level(r=0. 429,P<0. 05),but there was no correlation between BDNF and total bilirubin level(r=0. 278,P>0. 05). The serum BDNF level with craniocerebral MRI abnormal was ( 9. 53 ± 2. 77 ) μg/L, higher than that with craniocerebral MRI abnormal ((7. 81±3. 76) μg/L),but there was no statistical difference between them(t=1. 439,P>0. 05). Conclusion In severe neonatal hyperbilirubinemia, the body can secrete BDNF increasely. BDNF level is positivelycorrelated with B/ A level. As a marker of brain damage,BDNF is sensitive than craniocerebral MRI.
