Effect and Possible Mechanism of Elsibucol Inhibiting Atherosclerosis in Experimental Rabbits
10.3969/j.issn.1000-3614.2016.05.008
- VernacularTitle:艾赛布考抑制兔动脉粥样硬化的作用及可能机制
- Author:
Tingting LI
;
Yuan GUO
;
Jianning ZHANG
;
Tianjiao LIU
;
Jun LI
;
Yun ZHANG
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Hyperlipidemias;
Artery injuries;
Oxidative stress
- From:
Chinese Circulation Journal
2016;31(5):449-453
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Elsibucol is a metabolically stable derivative of probucol with the properties of anti-oxidation, anti-inflammation and anti-proliferation. We want to explore the effect of elsibucol on abdominal aorta injury in hypercholesterolemia rabbits. Methods: A total of 45 male New Zealand rabbits were divided into 3 groups: Control group, the rabbits were fed by high cholesterol diet, Elsibucol group, the rabbits received high cholesterol diet with 1% elsibucol and Probucol group, the rabbits received high cholesterol diet with 1% probucol.n=15 in each group. All animals were treated for 2 weeks followed by the procedure of abdominal aortic balloon injury and then, drug therapy was continued for 10 weeks. The area and load of atherosclerosis in abdominal aorta were evaluated by IVUS, the amount of macrophages in plaque were observed by immunohistochemistry, mRNA and protein expressions of MCP-1, MMP-9 were examined by RT-PCR and immunohistochemistry. Results: Compared with Control group, Elsibucol group showed decreased blood LDL-C and oxidative stress, decreased amount of macrophages and lower expression of inlfammatory factors in atherosclerosis plaque, reduced plaque area and load, allP<0.01. Compared with Probucol group, Elsibucol group presented even lower plaque area and load, allP<0.01. Conclusion: Elsibucol inhibits the progress of atherosclerosis in experimental rabbits via regulating blood lipids, anti-inlfammation and anti-oxidation.
