Preparation of PLGA Nanoparticles Loading Tetrandrine and Its Release in Vivo

VernacularTitle:汉防己甲素-P LGA纳米粒的制备与体外释放?
Author: Chen SHI ; Dehao FU ; Siwei ZHENG
Publication Type:Journal Article
Keywords: Tetrandrine; Poly( lactic-co-glycolic acid); Drug release; Nanoparticles
From: Herald of Medicine 2016;35(6):627-631
CountryChina
Language:Chinese
Abstract: Objective To prepare the PLGA nanoparticles( NPs) loading tetrandrine, investigate in vitro drug release behavior. Methods Tetrandrine loaded PLGA NPs were prepared by the emulsion solvent diffusion method and the preparation process was optimized by changing the stabilizer concentration and emulsion energy. The drug loading and entrapment efficiency were studied to evaluate the drug-loading property.The influence of particles size and pH value of release media on drug release behavior was investigated. Results Nanoparticles in the mean size of(203.4±2.8)nm had spherical shape and showed negative surface charge.Drug loading and entrapment efficiency was(2.17±0.10)% and(67.88±4.27)%, respectively.Tet-PLGA NPs retarded drug release in vitro, the cumulative release percentage was increased with the particle size increasing and it in acidic release medium showed a higher drug release amount. Conclusion Tetrandrine loaded PLGA nanoparticles have good entrapment efficiency, uniform particle size and can retard drug release in vitro.