The role of brain-derived neurotrophic factor in the antidepressant effect of ketamine
10.16571/j.cnki.1008-8199.2016.05.020
- VernacularTitle:脑源性神经营养因子在氯胺酮抗抑郁中的作用
- Author:
Jing WANG
;
Guangfen ZHANG
;
Jianjun YANG
;
Zhiqiang ZHOU
- Publication Type:Journal Article
- Keywords:
Ketamine;
Depression;
Brain-derived neurotrophic factor;
Mammalian target of rapamycin;
Glycogen synthase kinase 3
- From:
Journal of Medical Postgraduates
2016;29(5):538-541
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a common mental disease, which is the leading cause of suicide.Ketamine, a commonly used gener-al anesthetic in clinical practice, exerts a rapid and effective antidepressant effect, and reduces suicide ideation in patients with treat-ment-resistant depression quickly.Brain-derived neurotrophic factor ( BDNF) is a neurotrophic factor widely expressed in central nerv-ous system, the increase of which has been shown to be critical in the antidepressant effect of ketamine.This article aims to review the role of BDNF and its downstream signaling pathways in the antidepressant effect of ketamine.
