Research progress of long non-coding RNAs in colorectal cancer
10.16571/j.cnki.1008-8199.2016.05.024
- VernacularTitle:长链非编码 RNA 在结直肠癌中的研究进展
- Author:
Yang LIN
;
Lijian XU
- Publication Type:Journal Article
- Keywords:
Long non-coding RNA;
Colorectal cancer;
The expression level
- From:
Journal of Medical Postgraduates
2016;29(5):556-560
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs ( LncRNAs) are a class of RNA transcripts greater than 200 nt in length without the func-tion of protein encoding.LncRNAs, which consist of a great variety of categories and structures, regulate the associated gene expression on multiple levels, including chromatin modification, transcriptional and post-transcriptional regulation, and epigenetic modification. Moreover, LncRNAs are widely involved in the physiological and pathological processes.Recently, a large number of studies have found that the abnormal expression of LncRNAs is closely related to the occurrence, development, invasion and metastasis of tumor, and plays an essential role in pathogensis of colorectal cancer.In this paper, the function of LncRNAs in colorectal cancer is reviewed, which provides a theoretical evidence for its use in the diagnosis and treatment of colorectal cancer in clinical study.
