Cervical Vestibular Evoked Myogenic Potential in Diabetes Rats
10.3969/j.issn.1006-7299.2016.03.010
- VernacularTitle:糖尿病大鼠颈性前庭诱发肌源性电位的观察
- Author:
Yixin YUAN
;
Yong LIANG
;
Xiaolong LIU
;
Xueqin HUANG
;
Chen YANG
;
Wei ZHANG
;
Qi LI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Cervical vestibular voked myogenic potentials;
Vestibular function
- From:
Journal of Audiology and Speech Pathology
2016;24(3):260-264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To verify whether cervical vestibular evoked myogenic potential (cVEMP) can be used as an effective method to assess vestibular functions in diabetic rats ,we examined and analyzed cervical vestibular e-voked myogenic potential (cVEMP) in different duration diabetic rats and normal rats .Methods A total of 220 male SD rats were randomly divided into control group (n=20) and diabetes group (n= 200) .The diabetic rats were further divided into 4 ,6 ,8 ,10 ,and 12 week groups (40 rats each group) according to the diabetes duration . Diabetes was induced by STZ .The general situation ,ABR and cVEMP were conducted in all the groups .Results All diabetic groups appeared typical diabetic symptoms including polydipsia ,polyuria ,more food ,weight loss (P<0 .01) and blood glucose elevation (P<0 .01) .The threshold of ABR was significantly elevated (P<0 .05) in the 6 , 8 ,10 ,and 12 week diabetic group .Compared to the normal group ,the threshold of cVEMP was significantly elevat-ed in 8 week(53 .87 ± 11 .16 dB nHL) ,10 week(67 .00 ± 12 .74 dB nHL) ,12 week(67 .00 ± 9 .23 dB nHL) diabetes groups(P<0 .01) and the mean latency of P1 peak was significantly prolonged (P<0 .01) in 8 week(5 .01 ± 0 .33 ms) ,10 week(5 .37 ± 0 .45 ms) ,and 12 week(5 .39 ± 0 .24 ms) .The mean latency of N1 peak was significantly pro-longed (P<0 .01) in 10 week (8 .98 ± 0 .86 ms) ,and 12 week (9 .08 ± 0 .45 ms) compared to the control group .As to P1 - N1 amplitudes ,there was no significantly difference among all groups (P> 0 .05) .Conclusion In the cVEM P test ,the threshold increased ,the PI peak latency and N1 peak latency prolonged from the 8 th week of diabe-tes rats models .Vestibular functions were descent gradually due to different degrees of vestibular end -organ impairment . All data indicated that VEM P could be used as an early diagnostic method .
