The association between skeletal maturation and adrenal androgen levels in obese children and adolescents.
10.6065/apem.2017.22.2.108
- Author:
Sung Eun KIM
1
;
Joon Weon JANG
;
Moon Bae AHN
;
Shin Hee KIM
;
Won Kyoung CHO
;
Kyoung Soon CHO
;
So Hyun PARK
;
Min Ho JUNG
;
Byoung Kyu SUH
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. jmhpe@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Obesity;
Androgens;
Dehydroepiandrosterone sulfate;
Child
- MeSH:
Adolescent*;
Age Determination by Skeleton;
Androgens;
Body Mass Index;
Child*;
Dehydroepiandrosterone Sulfate;
Fasting;
Homeostasis;
Humans;
Insulin;
Insulin Resistance;
Linear Models;
Obesity;
Overweight
- From:Annals of Pediatric Endocrinology & Metabolism
2017;22(2):108-114
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study aimed to investigate the association between skeletal maturation and adrenal androgen levels in obese children and adolescents. METHODS: Fifty-three children and adolescents (aged 7–15 years) diagnosed as obese or overweight were investigated. Anthropometric measurements, bone age (BA) determination, serum biochemical analyses, and hormonal measurements were performed. The difference between BA and chronological age (BA–CA, dBACA) was calculated and used to represent the degree of advanced skeletal maturation. RESULTS: Thirty-one subjects were classified into the obese group and 22 subjects into the overweight group. Insulin resistance as calculated by the homeostasis model assessment of insulin resistance (HOMA-IR) was significantly higher in the obese group than in the overweight group (4.03±2.20 vs. 2.86±1.11, P=0.026). The skeletal maturation of the obese group was advanced, but the dBACA did not differ between the obese and overweight groups statistically (1.43±1.35 vs. 0.91±1.15, P=0.141). Serum dehydroepiandrosterone sulfate (DHEA-S) levels were significantly higher in subjects with dBACA>1 compared to those with dBACA≤1 (104.3±62.2 vs. 59.6±61.0, P=0.014). Correlation analyses demonstrated that dBACA was positively correlated with body mass index standard deviation scores (r=0.35, P=0.010), fasting insulin (r=0.36, P=0.009), HOMA-IR (r=0.30, P=0.031), and insulin-like growth factor-binding protein-3 (r=0.331, P=0.028). In multivariate linear regression analysis, HOMA-IR (P=0.026) and serum DHEA-S (P=0.032) were positively correlated with the degree of advanced skeletal maturation. CONCLUSION: Advanced skeletal maturation is associated with increased insulin resistance and elevated DHEA-S levels in obese children and adolescents.
