Correlation of endothelial inflammation in patients with acute myocardial infarction with no-reflow and severity of coronary lesion
10.7652/jdyxb201603006
- VernacularTitle:急性心肌梗死患者内皮炎症与无复流及冠脉病变严重程度的相关性
- Author:
Jing ZHOU
;
Chunyan ZHANG
;
Weidong MA
;
Feng GAO
;
Shengling YAN
;
Yanyang MAO
;
Yan ZHANG
;
Shan JIA
;
Congxia WANG
- Publication Type:Journal Article
- Keywords:
endothelial microparticle;
soluble intercellular adhesion molecule-1;
acute myocardial infarction;
no-reflow;
Gensini score
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(3):331-335
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of endothelial inflammation in patients with acute myocardial infarction (AMI)with no-reflow and severity of coronary lesion.Methods A total of 120 patients with AMI were all treated with percutaneous coronary intervention (PCI).The patients who had intraoperative no-reflow were in case group (n=40).The patients who were also treated by PCI but did not have no-reflow in the same period in our hospital served as the control group (n=80).According to the results of coronary angiography, no-reflow group patients were divided into three subgroups:single lesion group (n=14),two-lesion group (n=10), and three-lesion group (n=1 6 ).We monitored these patients’immediate postoperative endothelial microparticles (EMPs)and soluble intercellular adhesion molecule-1 (sICAM-1 )levels in both groups with flow cytometry and ELISA methods.Results In the case group,immediate postoperative EMPs and sICAM-1 levels in the blood circulation were significantly higher than those in the control group.EMPs area and sICAM-1 area under the curve in the case group were 0.755 and 0.701,which showed that EMPs and sICAM-1 levels had a good correlation with the occurrence of non-reflow in AMI patients after PCI.Gensini score and EMPs level rose with the increase of the lesion counts,and the level of EMPs was positively correlated with Gensini score.Conclusion In patients with AMI,the EMPs and sICAM-1 levels can well predict the occurrence of no-reflow and are of some value in predicting the severity of coronary lesion.
