The variation and significance of plasma hs-CRP,IL-6 and sIL-6R levels in coronary heart disease patients
10.7652/jdyxb201603010
- VernacularTitle:冠心病患者血浆hs-CRP、IL-6和可溶性IL-6受体水平的变化及意义
- Author:
Qi GUO
;
Weidong MA
;
Chunyan ZHANG
;
Yan ZHANG
;
Congxia WANG
;
Shan JIA
;
Haoyu WU
;
Yang ZHENG
- Publication Type:Journal Article
- Keywords:
coronary heart disease;
interleukin-6;
soluble IL-6 receptor;
Gensini score;
C reactive protein (CRP);
angina pectoris;
coronary angiography (CAG)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(3):349-352
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of high sensitivity C reactive protein (hs-CRP), interleukin-6 (IL-6)and soluble IL-6 receptor (sIL-6R)with the severity of clinical symptoms and coronary artery lesions in coronary heart disease (CHD)patients.Methods A total of 522 CHD patients were recruited and divided into three groups:stable angina pectoris (SAP),unstable angina pectoris (UAP)and acute myocardial infarction (AMI)groups.Another 102 healthy individuals served as normal controls (NCs).We calculated Gensini score according to the result of coronary angiography (CAG),collected clinical data and compared the groups. Multiple linear regression analysis was used to investigate the relationship of hs-CRP,IL-6 and sIL-6 R with Gensini score.Results The plasma hs-CRP,IL-6 levels were significantly higher and sIL-6R level was signficantly lower in SAP,UAP and AMI groups than in NC group (P<0 .0 5 ).There was a positive correlation between IL-6 level and Gensini score but a negative correlation between sIL-6 R and Gensini score presented by multiple linear regression analysis (P<0.05 ).Conclusion In CHD patients,plasma hs-CRP,IL-6 and sIL-6R levels are significantly related to the severity of clinical manifestations and coronary artery stenosis.These indicators may help predict the severity of CHD.
