Association between single-nucleotide polymorphisms of vascular endothelial growth factor gene and Alzheimer’s disease in Shaanxi Han population
10.7652/jdyxb201603012
- VernacularTitle:血管内皮生长因子基因多态性与陕西汉族阿尔茨海默病的相关性研究
- Author:
Xiaoying GENG
;
Aixiang ZHANG
;
Jian QIAN
;
Gang GUO
;
Lulu ZHANG
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease;
vascular endothelial growth factor;
single nucleotide polymorphism;
Shaanxi Han population
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(3):358-362
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between 8 single nucleotide polymorphisms (SNPs)of vascular endothelial growth factor (VEGF ) gene and the risk of Alzheimer’s disease (AD ) in Shaanxi Han population.Methods We examined the potential association between AD and 8 SNPs of VEGF gene using the MassARRAY system.The participants enrolled in this study included 214 patients with AD and 249 healthy controls from Shaanxi Han population.SPSS16.0 and Haploview 4.2 were employed to analyze differences in genotypes, alleles and haplotypes between the two groups.Results The results showed that rs3025039 (3’UTR)were significantly associated with AD (P<0.05).Greater frequency of rs3025039 T allele (P=0.008,OR=1.527,95%CI=1.116-2.088)was found in AD subjects.Furthermore,strong linkage disequilibrium (LD)was observed in 2 locks (block1:rs699947-rs1570360-rs2010963;block 2:rs3024997-rs3024998-rs3025006)(D’>0.9).There were no significant haplotypes in block 1 and block 2 (P=0.034)found between the patients and controls.Conclusion These findings point to the role for VEGF gene polymorphisms (rs3025039)in AD of a Shaanxi Han population. Individuals with T allele of rs3025039 may be at a higher risk for AD.
