Expression of Trem-1 and its significance in psoriasis vulgaris
10.7652/jdyxb201603026
- VernacularTitle:髓样细胞触发受体-1在寻常型银屑病中的表达及意义
- Author:
Chen TU
;
Shuang WANG
;
Yang ZHANG
;
Jianwen REN
;
Xiaopeng WANG
;
Shengxiang XIAO
- Publication Type:Journal Article
- Keywords:
triggering receptor expressed on myeloid cells-1 (Trem-1 );
psoriasis vulgaris;
immunohistochemis-try;
Real-time PCR
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(3):428-431
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of triggering receptor expressed on myeloid cells-1 (Trem-1)in psoriatic vulgaris and normal skin tissues and blood,and to explore the potential pathogenesis of psoriasis.Methods Immunohistochemistry and Real-time PCR were used to detect the expression of Trem-1 in the blood and tissues of normal skin and psoriasis.Results The positive expression rate of Trem-1 in psoriatic lesion was significantly higher than normal tissue.Trem-1 was expressed in the whole epidermis,with a significant difference (P<0.05). The mRNA expression of Trem-1 was significantly higher in psoriatic skin tissues and blood than in normal skin tissues and blood (P<0.05).Moreover,the mRNA expression of Trem-1 was positively correlated with PASI (P<0.05).Conclusion Abnormal expression of Trem-1 might be related to the pathogenesis of psoriasis.Trem-1 will cure psoriasis vulgaris as the potential therapeutic target.
