A review for function of Wnt protein family in osteocyte
10.16571/j.cnki.1008-8199.2016.05.023
- VernacularTitle:W nt家族蛋白对骨细胞的作用研究进展
- Author:
Dalong WEI
;
Shan LAO
;
Gaobin LUO
- Publication Type:Journal Article
- Keywords:
Wnt signaling;
Osteoblastogenesis;
Osteoclastogenesis;
Bone metabolism
- From:
Journal of Medical Postgraduates
2016;29(5):551-555
- CountryChina
- Language:Chinese
-
Abstract:
Wnt signaling pathway has a critical role in differentiation, proliferation, supersession and metabolism of osteocyte. Although the principal components are relatively simple, however, the numerous components consisted of Wnt signaling participate in the reaction, including several LRPs ( low density lipoprotein receptor-related protein,LRP) , 19 different Wnt proteins and 19 different FZDs( frizzled receptor, FZD) , and non-canonical Wnt signaling and multiple inhibitors of Wnt signaling.The Wnts linked to mem-brane coreceptor and activated downstream of canonical Wnt signaling or non-canonical Wnt signaling, In addition, different Wnts had different roles in differentiation, bone formation and bone absorption of osteocyte.This review aims to understand the relationship be-tween Wnt signaling and osteocyte metabolism and bone diseases, by analyzing a variety of factors and the process of Wnt protein and Wnt signaling pathway in activity of osteocyte.
