Anti-tumor research targeting IAPs
10.3969/j.issn.1001-1978.2016.05.005
- VernacularTitle:以IAPs为靶点的抗肿瘤研究进展
- Author:
Yingying HUANG
;
Hao LIU
- Publication Type:Journal Article
- Keywords:
tumour;
apoptosis;
IAPs;
caspases;
Smac;
NF-κB
- From:
Chinese Pharmacological Bulletin
2016;32(5):612-615
- CountryChina
- Language:Chinese
-
Abstract:
Apoptosis inhibitors ( inhibitor of apoptosis proteins, IAPs) are a class of highly conserved apoptotic endogenous anti-cytokine family, primarily by inhibiting caspase activity and par-ticipation in regulation of nuclear factor NF-κB inhibition of ap-optosis. caspases cascade of protease activation is a central part of the apoptotic process, Bcl-2 family proteins and IAPs family proteins are the main controlling factors. In recent years, we found that abnormal expression of some IAPs members is closely associated with the tumor, a potential target for cancer therapy. Therefore, this paper reviews the major protein associated with IAPs family and anti-tumor research targeting IAPs.
