MicroRNAs：potential new targets for allergic diseases
10.3969/j.issn.1001-1978.2016.05.006
- VernacularTitle:MicroRNAs：过敏性疾病的潜在新靶点
- Author:
Xiaoyu WANG
;
Xi YU
;
Yan WANG
;
Yu TAO
;
Can WANG
;
Kaifan BAO
;
Lyu JI
;
Min HONG
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
allergic diseases;
allergic asthma;
al-lergic dermatitis;
allergic rhinitis;
target
- From:
Chinese Pharmacological Bulletin
2016;32(5):616-619
- CountryChina
- Language:Chinese
-
Abstract:
Allergic diseases such as allergic asthma, allergic der-matitis, allergic rhinitis, are polygenic diseases, involving the interaction between the environment, genes and immunity. In the past few decades, the incidence rate of allergic diseases in-creased predominantly and influenced the quality of people's lives seriously, so looking for new targets for the prevention and treat-ment of allergic diseases and drugs with less adverse reaction be-comes a hot topic for researchers. MicroRNAs(miRNAs)are a class of endogenous non-coding small RNAs that mediate nega-tively posttranscriptional regulation of gene expression by targe-ting specific mRNA sequences to inhibit the translation of mR-NAs. They are widely involved in the biological processes of cell differentiation, immune response and tumor development. The study shows that miRNAs can control the occurrence and devel-opment of allergic diseases. Studying the regulatory role of miR-NAs in allergic diseases has important implications for exploring the immunopathological mechanisms and discovering new thera-peutic targets of drugs.
