The Expression of STAT3 and SOCS3 Protein in the Middle Ear Cholesteatoma
10.3969/j.issn.1006-7299.2016.03.011
- VernacularTitle:STAT3和 SOCS3蛋白在中耳胆脂瘤中的表达及意义
- Author:
Fanglei YE
;
Meng LI
;
Shichao LI
;
Le WANG
;
Kun ZHAO
;
Xiaodan ZHU
;
Ting ZHANG
- Publication Type:Journal Article
- Keywords:
Signal transducer and activator of transcription 3(STAT3);
Suppressor of cytokine signaling 3 (SOCS3);
Cholesteatoma;
Middle ear
- From:
Journal of Audiology and Speech Pathology
2016;24(3):265-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of signal transducer and activator of transcription 3 (STAT3) and Suppressor of cytokine signaling 3(SOCS3) in the middle ear cholesteatoma epithelium ,and the possible roles of STAT3 and SOCS3 in middle ear cholesteatoma .Methods The immunohistochemical assay was used to detect ex-pression of STAT3 and SOCS3 protein in 30 cases of middle ear cholesteatoma epithelial tissue and 20 cases of nor-mal external auditory canal skin tissues as the control group .Results STAT3 immunoreactivity was detected in the nuclei and cytoplasm of epithelial cells .The expression rates of STAT3 in middle ear cholesteatoma epithelial tissue were 76 .7% and higher than in the normal epithelium (25 .0% ) .The differences between the two groups were sta-tistically significant (P<0 .05) .SOCS3 immunoreactivity was detected in the cytoplasm of epithelial cells .The ex-pression rates of SOCS3 in middle ear cholesteatoma epithelial tissue were 33 .3% and lower than in the normal epi-thelium (65 .0% ) .The differences were statistically significant (P<0 .05) .The expression of STAT3 and SOCS3 in the middle ear cholesteatoma had negative correlation (r= - 0 .476 ,P<0 .05) .Conclusion The abnormal ex-pression of STAT3 and SOCS3 in the middle ear cholesteatoma may be involved in hyper proliferation and anti -ap-optosis of cholesteatoma cell ,and play an important role in the formation and development of middle ear cholesteatoma .
