Effects of active component of Radix Isatidis on anti-anoxia and anti-fatigue in mice
10.3969/j.issn.1001-1978.2016.05.023
- VernacularTitle:板蓝根活性组分对小鼠耐缺氧及抗疲劳作用的实验研究
- Author:
Jiping LI
;
Tingting SUN
;
Tianjiao HU
;
Moxiang LIU
- Publication Type:Journal Article
- Keywords:
active component of Radix Isatidis ( AC-RI);
anti-anoxia;
anti-fatigue;
superoxide dismutase;
maleic dialdehyde;
blood urea nitrogen;
blood lactic acid;
liver glycogen
- From:
Chinese Pharmacological Bulletin
2016;32(5):712-715
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effects of active com-ponent of Radix Isatidis ( ACRI ) on anti-anoxia and anti-fatigue in mice and investigate its possible mecha-nism. Methods Based on the weights, the mice were randomly divided into 5 groups: blank control group, ACRI 25, 50 and 100 mg·kg-1 groups, positive drug ( American ginseng liquid) control group 3 mL·kg-1 . Drugs were administered to the mice for about 14 con-secutive days, and during the experiment general situa-tions of mice were observed. The experiment of bearing hypoxia at normal pressure and the experiment of swim-ming while weight-bearing were conducted to study the effect of ACRI on anti-anoxia and anti-fatigue in mice. Then the superoxide dismutase ( SOD ) activities, the content of maleic dialdehyde ( MDA ) of mice serum and liver and blood urea nitrogen, blood lactic acid, liver glycogen were detected, in order to investigate its mechanism. Results ACRI decreased the growth rate of body weight in mice significantly, obviously pro-longed the survival time of anoxic mice at normal pres-sure and the swimming time of loaded mice, enhanced the SOD activities of mice blood and liver, decreased the MDA content of mice blood and liver, increased the content of liver glycogen, and decreased the blood urea nitrogen and blood lactic acid in mice after swim-ming. Conclusion ACRI has the anti-anoxia and anti-fatigue functions.
