Correlation of glycated hemoglobin,fibrinogen and cystatin C with the severity of coronary artery lesions in non-diabetic patients
10.7652/jdyxb201603009
- VernacularTitle:非糖尿病患者糖化血红蛋白、纤维蛋白原及胱抑素C与冠脉狭窄程度的关系
- Author:
Weidong MA
;
Xiaohuan LIU
;
Chunyan ZHANG
;
Congxia WANG
;
Yan ZHANG
;
Shan JIA
;
Yongqin LI
;
Zhenhua HAN
;
Yang ZHENG
- Publication Type:Journal Article
- Keywords:
non-diabetes;
glycated hemoglobin;
fibrinogen;
cystatin C;
coronary artery stenosis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(3):344-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of glycated hemoglobin (HbA1c),fibrinogen (Fbg)and cystatin C (Cys C)with the severity of coronary artery lesions in non-diabetic patients.Methods We enrolled 358 patients who received coronary angiography (CAG)in this study.They were divided into coronary artery disease (CAD)group and non-CAD group according to CAG results.Moreover,according to different clinical types of CAD,all the CAD patients were further classified into stable angina pectoris (SAP)group and acute coronary syndrome (ACS)group.We calculated Gensini score and divided CAD group into A,B and C subgroups by Gensini score.HbA1 c,Fbg,Cys C and other clinical data were measured and compared between groups,and the correlation analysis was used to find the relationship of HbA1c,Fbg and Cys C with Gensini score.Results The levels of HbA1 c,Fbg and Cys C were significantly higher in groups A,B and C than in non-CAD group.When Gensini score increased,the three indexes were increased too (P<0.05).The levels of HbA1c,Fbg and Cys C were significantly higher in ACS group than in SAP and non-CAD group (P<0.05).After adjustment for the influencing factors, HbA1 c was still associated with Fbg (P<0 .0 5 ).The levels of HbA1 c and Fbg were closely related to Gensini score (P<0.05).Conclusion In non-diabetes patients,HbA1c and Fbg are significantly related to the severity of coronary artery stenosis,and Cys C may not be an independent risk factor of coronary artery stenosis.
