Association between estrogen receptor gene polymorphism and lipid metabolism in the Ningxia Hui population
10.7652/jdyxb201603024
- VernacularTitle:宁夏回族人群雌激素受体基因多态性及与血脂的关联性
- Author:
Shuya LI
;
Deyu YANG
;
Jinhai TIAN
;
Jingjing YU
;
Rong MA
;
Qi HUANG
;
Xu ZHANG
;
Jia WANG
;
Min JIANG
- Publication Type:Journal Article
- Keywords:
estrogen receptor gene;
SNP;
Ningxia Hui population;
lipid
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(3):418-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distribution of rs2234693 and rs9340799 of estrogen receptor (ER)gene and the relationship between them and lipid metabolism in the Ningxia Hui group,China.Methods We used cluster sampling method to select 5 3 3 cases of Ningxia Yinchuan communities of Hui. SNP genotyping was performed using the Sequenom MassARRAY platform.Results ① The frequencies of the distribution of each genotype of rs2234693 in Ningxia Hui population were the same as those in Chinese Han and Dai,Americans, Europeans,and Japanese (P>0.05).The distribution of each genotype of rs9340799,especially AA genotype,was different from that in Europeans (P<0 .0 5 ).② The body mass index in dyslipidemia group was significantly different from that in the control group (P<0.01).③ The risk of dyslipidemia in subjects with GG genotype of rs9340799 was 2.97 times higher than that in subjects with other genotypes (OR=2.97,P<2.97 ).After adjustment of gender,age,and body mass index (BMI),estrogen level was also 2.76 times higher (OR=2.76,P<0.05).(4)The frequency of C-G in rs2234693-rs9340799 haplotype was greater than that in the control group,but without any significant difference (P>0.05).Conclusion ER genes distribution in the Hui nationality of Ningxia is significantly different from that in other races;rs2234693 has no obvious relationship with the occurrence of dyslipidemia while GG genotype in SNP rs9340799 significantly increases the risk of lipid metabolism disorders.
