Expression and clinical significance of P-selectin in colorectal cancer cells
10.11958/20150110
- VernacularTitle:大肠癌组织癌细胞中P-选择素的表达及其临床病理意义
- Author:
Chunying LUO
;
Bingchen HUANG
;
Qin HUANG
;
Jiaxing CHEN
;
Haishan LU
;
Yesheng WEI
;
Junli WANG
;
Zhaoquan HUANG
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
P-selectin;
immunohistochemistry;
colorectal cancer
- From:
Tianjin Medical Journal
2016;44(5):540-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of P-selectin in colorectal cancer cells. Methods The protein expression of P-selectin was detected by immunohistochemistry in colorectal cancer tissues ( n=116) and corresponding non-tumor normal mucosa(n=57). The differences of P-selectin expression in colorectal cancer tissues, corre?sponding non-tumor normal mucosa and the clinical pathological significance were compared and analysed in two groups. Results The expression of P-selectin protein was found not only in vascular endothelial cells but also in colorectal cancer cells. The positive rate of P-selectin expression was apparently higher in colorectal cancer cells (77.6%, 90/116) than that in normal mucosa (17.5%, 10/57,χ2=56.49, P<0.05). However, there were no significance in positive rates of P-selectin in colorectal cancer cells between tumors with different diameters, different degrees of differentiation, different depths of infiltration and with or without lymph node metastasis (80.6%vs. 74.1%, 79.0%vs. 74.3%, 78.4%vs. 76.9%, 82.7%vs. 73.4%, P>0.05). Conclusion The high expression of P-seletin in colorectal cancer cells is an important characteristic of colorectal cancer.
